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The function of SIK1 in tumorigenesis. SIK1 is actually a tumor suppressor gene, which plays an essential regulatory job in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and has an effect on most cancers cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 also can en